Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells
Mayuko Sugimoto, Risa Ko, Hiromi Goshima, Atsushi Koike, Makio Shibano, Ko Fujimori
Topics & Concepts
FormononetinProtein kinase BPI3K/AKT/mTOR pathwayMAPK/ERK pathwaySH-SY5YReactive oxygen speciesApoptosisChemistryKinaseProtein kinase ACell biologyProgrammed cell deathBiologyBiochemistryCell cultureGenisteinEndocrinologyNeuroblastomaGeneticsDaidzeinGenomics, phytochemicals, and oxidative stressPhytoestrogen effects and researchPhytochemicals and Antioxidant Activities