Navigating the landscape of EGFR TKI resistance in EGFR-mutant NSCLC — mechanisms and evolving treatment approaches
Jing Zhao, Wanting Xu, Fei Zhou, Xiangyu Zhang, Mo Zhou, Da Miao, Yu Lan, Yongchang Zhang, Junqiang Fan, Caicun Zhou, Wen Li, Tony Mok, Xiuning Le, Molly Li, Yang Xia
Topics & Concepts
MedicineErlotinibGefitinibAcquired resistanceAfatinibDrug resistanceEGFR inhibitorsClinical trialTherapeutic approachTyrosine kinasePersonalized medicineCancer researchLung cancerTargeted therapyBioinformaticsOsimertinibResistance (ecology)Erlotinib HydrochloridePrecision medicineCombination therapyEpidermal growth factor receptorTyrosine-kinase inhibitorComputational biologyCancerDruggabilityLung Cancer Treatments and MutationsCancer Immunotherapy and BiomarkersRadiomics and Machine Learning in Medical Imaging