Suppression of glutathione system and upregulation of caspase 3-dependent apoptosis mediate rohypnol-induced gastric injury
Roland Eghoghosoa Akhigbe, David Tolulope Oluwole, Tolulope E. Adegoke, Moses Agbomhere Hamed, Davinson Chuka Anyogu, Ayodeji Folorunsho Ajayi
Abstract
This study revealed that rohypnol induced gastric injury by suppressing glutathione content and COX-2 activity, and upregulating caspase 3-dependent apoptosis, which was partly reversed by rohypnol withdrawal.
Topics & Concepts
GlutathioneMalondialdehydeGlutathione peroxidaseSuperoxide dismutaseChemistryApoptosisNitric oxideInternal medicinePharmacologyCatalaseDownregulation and upregulationEndocrinologyOxidative stressMedicineBiochemistryEnzymeGeneGinger and Zingiberaceae researchTraditional Chinese Medicine AnalysisNephrotoxicity and Medicinal Plants