Direct conversion of amino acids to oxetanol bioisosteres <i>via</i> photoredox catalysis
Avelyn Mae Delos Reyes, Christopher S. Nieves Escobar, Alberto Viñas Muñoz, Maya I. Huffman, Derek S. Tan
Abstract
Carboxylic acids can be converted directly to bioisosteric 3-oxetanols by leveraging the unique reactivity of photoredox catalysis. Cr-mediated and Cr-free variants of the reaction have been developed, both having quantum yields greater than 5.
Topics & Concepts
Photoredox catalysisReactivity (psychology)CatalysisChemistryCombinatorial chemistryOrganic chemistryPhotocatalysisMedicinePathologyAlternative medicineRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods