Development of magnetic nanoparticles with double silica shells of different porosities for efficient siRNA delivery to breast cancer cells
Qing Bao, Xiangyu Liu, Yan Li, Tao Yang, Yue Hui, Mingying Yang, Chuanbin Mao
Abstract
Silica-based magnetic nanoparticles are designed to deliver siRNA to triple negative breast cancer cells. The cells are killed due to siRNA-induced apoptosis upon the magnetic field-enhanced efficient cellular uptake and endosome escape of siRNA.
Topics & Concepts
EndosomeApoptosisMagnetic nanoparticlesNanoparticleTriple-negative breast cancerCancer cellCancerBreast cancerNanotechnologyMaterials scienceCancer researchCell biologySmall interfering RNABiophysicsChemistryCellTransfectionMedicineBiologyBiochemistryGeneInternal medicineAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery