Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
Parisha P. Shah, Wenjian Lv, Joshua H. Rhoades, Andrey Poleshko, Deepti Abbey, Matthew A. Caporizzo, Ricardo Linares-Saldana, Julie Heffler, Nazish Sayed, Dilip Thomas, Qiaohong Wang, L. Stanton, Kenneth Bedi, Michael P. Morley, Thomas P. Cappola, Anjali Owens, Kenneth B. Margulies, David B. Frank, Joseph C. Wu, Daniel J. Rader, Wenli Yang, Benjamin L. Prosser, Kiran Musunuru, Rajan Jain
Topics & Concepts
LMNALaminBiologyNuclear laminaChromatinPhenotypeEpigeneticsCell biologyGeneticsInduced pluripotent stem cellGeneNuclear proteinTranscription factorEmbryonic stem cellNuclear Structure and FunctionGenomics and Chromatin DynamicsRNA Research and Splicing