Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy
Naseeb Kaur Malhi, Claire Allen, Elizabeth A. Stewart, Katie L. Horton, Federica Riu, Jennifer Batson, Winfried M. K. Amoaku, Jonathan C. Morris, Kenton P. Arkill, David O. Bates
Abstract
b splicing is induced by hyperglycemia through PKC-mediated activation of SRPK1 in RPE cells, increasing their permeability and angiogenic capability. SRPK1 inhibitors can be given as eye drops to reduce retinal permeability and edema in diabetic retinopathy.
Topics & Concepts
Diabetic retinopathySerineArginineVascular permeabilityRetinalProtein kinase CDiabetic macular edemaProtein kinase AMedicineChemistryOphthalmologyPharmacologyKinasePhosphorylationInternal medicineEndocrinologyBiochemistryDiabetes mellitusAmino acidRetinal Diseases and TreatmentsRetinal Development and DisordersRetinal and Macular Surgery