Cinnamaldehyde decreases the invasion and u-PA expression of osteosarcoma by down-regulating the FAK signalling pathway
Shu‐Chen Chu, Yih‐Shou Hsieh, Li‐Sung Hsu, Chin-Yin Lin, Yi-An Lai, Pei‐Ni Chen
Abstract
-cadherin. Importantly, the oral administration of cinnamaldehyde remarkably suppressed the pulmonary metastasis of osteosarcoma in mice. Results indicated that cinnamaldehyde has therapeutic potential for inhibiting osteosarcoma metastasis.
Topics & Concepts
OsteosarcomaCinnamaldehydeCancer researchFibronectinFocal adhesionMetastasisChemistryMesenchymal stem cellCell migrationActivator (genetics)CadherinPhosphorylationCell biologyBiologyCellMedicineCancerInternal medicineBiochemistryReceptorCatalysisProtease and Inhibitor MechanismsCell Adhesion Molecules ResearchCell death mechanisms and regulation