Copper-doped PDA nanoparticles with self-enhanced ROS generation for boosting photothermal/chemodynamic combination therapy
Xuan Wang, Ka Hong Wong, Yuying Yin, Zian Wang, Meiwan Chen
Abstract
; and (4) the delivery of curcumin further depleted GSH to increase cytotoxic ˙OH, which promoted the thermal sensitivity of tumor cells and led to cell apoptosis. FPCCD exhibited efficient anti-tumor efficacy in C6 tumor-bearing mice, representing a potential strategy for enhancing CDT/PTT through self-enhanced ROS generation.
Topics & Concepts
Photothermal therapyChemistryNanoparticleFolic acidGlutathioneCurcuminBoosting (machine learning)ApoptosisCancer therapyCopperCancer researchBiophysicsNanotechnologyBiochemistryCancerMaterials scienceMedicineBiologyInternal medicineComputer scienceEnzymeMachine learningOrganic chemistryNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery