Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability
Anika Gupta, Kathryn Weinand, Aparna Nathan, Saori Sakaue, Martin Jinye Zhang, Accelerating Medicines Partnership RA/SLE Program and Network, Laura T. Donlin, Kevin Wei, Alkes L. Price, Tiffany Amariuta, Soumya Raychaudhuri
Topics & Concepts
BiologyAutoimmune diseaseImmune systemDiseaseHeritabilityAutoimmunityGeneticsRegulatory T cellImmunologyCellComputational biologyT cellAntibodyMedicinePathologyIL-2 receptorT-cell and B-cell ImmunologyImmune Cell Function and InteractionSingle-cell and spatial transcriptomics