Isolable small-molecule cysteine sulfenic acid
Tsukasa Sano, Ryosuke Masuda, Shohei Sase, Kei Goto
Abstract
An isolable small-molecule cysteine sulfenic acid (Cys-SOH) protected by a molecular cradle was synthesized by direct oxidation of the corresponding cysteine thiol and its structure was established by X-ray crystallographic analysis. Studies on biologically relevant reactivity indicated its usefulness as a biorepresentative small-molecule sulfenic acid model.
Topics & Concepts
Sulfenic acidChemistryCysteineThiolReactivity (psychology)MoleculeSmall moleculeStereochemistrySulfenamideCombinatorial chemistryOrganic chemistryBiochemistryEnzymeNatural rubberPathologyAlternative medicineMedicineVulcanizationSulfur-Based Synthesis TechniquesOrganic Chemistry Cycloaddition ReactionsClick Chemistry and Applications