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Securinine induces mitotic block in cancer cells by binding to tubulin and inhibiting microtubule assembly: A possible mechanistic basis for its anticancer activity

Shabeeba M. Ashraf, Susobhan Mahanty, Krishnan Rathinasamy

2021Life Sciences12 citationsDOI

Topics & Concepts

HeLaMicrotubuleTubulinCell biologyChemistryMitosisApoptosisCytotoxicityCell cultureIn vitroSpindle apparatusCancer cellCellMolecular biologyBiologyBiochemistryCell divisionCancerGeneticsPhytochemistry and Bioactivity StudiesTraditional and Medicinal Uses of AnnonaceaePhytochemical compounds biological activities
Securinine induces mitotic block in cancer cells by binding to tubulin and inhibiting microtubule assembly: A possible mechanistic basis for its anticancer activity | Litcius