Biological behavior of nanoparticles with Zr-89 for cancer targeting based on their distinct surface composition
Pyeong Seok Choi, Jun Young Lee, Seung Dae Yang, Jeong Hoon Park
Abstract
Zr-incorporated iron oxide nanocomposite is significantly stable for radiolabeling despite various surface modifications, allowing the potential carrier to specifically target cancer cells. The strategy of utilizing the biocompatible PEI and PVP surface coating system for negative charged nanoparticles such as iron oxide will afford enhanced biological application.
Topics & Concepts
Materials sciencePolyvinylpyrrolidoneNanoparticleIron oxide nanoparticlesNanocompositeNanotechnologyInternalizationPolymerIron oxideCoatingChemical engineeringCancer cellOxideCancerChemistryPolymer chemistryComposite materialBiochemistryMedicineMetallurgyEngineeringInternal medicineCellRadiopharmaceutical Chemistry and ApplicationsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery