High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling
De Xie, Hairong Zhao, Jiaming Lu, Furong He, Weidong Liu, Wei Yu, Qiang Wang, Ichiro Hisatome, Tetsuya Yamamoto, Hidenori Koyama, Jidong Cheng
Abstract
Hyperuricemia and nonalcoholic fatty liver disease are global public health problems, which are strongly associated with metabolic syndrome. In this study, we demonstrate that uric acid induces hepatic fat accumulation via the ROS/JNK/AP-1 pathway. This study identifies a new mechanism of NAFLD pathogenesis and new potential therapeutic strategies for HUA-induced NAFLD.
Topics & Concepts
HyperuricemiaNonalcoholic fatty liver diseaseUric acidFatty liverEndocrinologyChemistrySteatosisInternal medicineLipogenesisBeta oxidationLipid metabolismFatty acid synthaseReactive oxygen speciesBiochemistryBiologyFatty acidMedicineDiseaseGout, Hyperuricemia, Uric AcidLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects