The Impact of Periodontal Disease on Preterm Birth and Preeclampsia
Panagiotis Tsikouras, Efthymios Oikonomou, Konstantinos Nikolettos, Sotiris Andreou, Dimitrios Kyriakou, Christos Damaskos, Nikolaos Garmpis, Vassiliki Monastiridou, Theopi Nalmpanti, Αnastasia Bothou, Georgios Iatrakis, Nikolaos Nikolettos
Abstract
This review delves into the possible connection between periodontitis and negative pregnancy outcomes, such as preeclampsia and preterm birth. It highlights the potential influence of an unidentified microbial factor on preeclampsia and the effects of inflammatory responses on the rate of preterm births. Furthermore, it underscores the prevalent occurrence of oral ailments within the populace and their significant repercussions on quality of life. Hormonal fluctuations during pregnancy may exacerbate oral conditions such as pregnancy gingivitis and periodontitis, necessitating bespoke therapeutic approaches that take into account potential fetal ramifications. Periodontal disease, characterized by microbial attack and inflammatory response, results in tissue destruction and tooth loss. The oral cavity's susceptibility to bacterial colonization, which is primarily due to its role as a site for food intake, is highlighted. Furthermore, research indicates a correlation between inflammatory responses and factors such as prostaglandin E2 and IL-1β, and preterm birth. Therapeutic interventions are a focus of international research, with efforts being aimed at optimizing outcomes through larger studies involving pregnant women.