Induced regulatory T cells suppress Tc1 cells through TGF-β signaling to ameliorate STZ-induced type 1 diabetes mellitus
Li Zhou, Xuemin He, Peihong Cai, Ting Li, Rongdong Peng, Junlong Dang, Yue Li, Haicheng Li, Feng Huang, Guojun Shi, Chichu Xie, Yan Lü, Yanming Chen
Topics & Concepts
NOD miceStreptozotocinImmune systemType 1 diabetesRegulatory T cellImmunologyCytotoxic T cellEffectorTransforming growth factorCellPI3K/AKT/mTOR pathwayT cellDiabetes mellitusMedicineAutoimmunityBiologySignal transductionCell biologyEndocrinologyIL-2 receptorIn vitroBiochemistryGeneticsDiabetes and associated disordersT-cell and B-cell ImmunologyImmune Cell Function and Interaction