Hemodialysis and COVID-19: An Achilles’ Heel in the Pandemic Health Care Response in the United States

Abstract

In December 2019, China reported a cluster of pneumonia cases in Wuhan, Hubei Province, that subsequently were associated with the novel coronavirus, 2019-nCoV.1World Health OrganizationNovel coronavirus — China. 2020.https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/Date accessed: March 26, 2020Google Scholar Through person-to-person transmission, this novel coronavirus spread worldwide, with widespread cases of coronavirus disease 2019 (COVID-19). In an attempt to mitigate the effects of the COVID-19 pandemic and “flatten-the-curve,” such that hospitals would not be overwhelmed at any given time with COVID-19 cases, various levels of social distancing were introduced in the United States. On March 16, 2020, the Centers for Disease Control and Prevention (CDC) and the White House launched a “15 Days to Slow the Spread” campaign, requesting that anyone who feels sick, is in a household with someone who has tested positive for COVID-19, or is elderly or with a serious underlying medical condition stay at home.2The White HouseThe President's coronavirus guidelines for America: 15 days to slow the spread. March 16, 2020.https://www.whitehouse.gov/wp-content/uploads/2020/03/03.16.20_coronavirus-guidance_8.5x11_315PM.pdfDate accessed: March 25, 2020Google Scholar Additionally, they requested that people work or engage in school remotely when possible, avoid discretionary travel, and avoid gatherings of more than 10 people. Although variably adopted by states, with some states such as Washington, California, and New York issuing broad restrictions early in the pandemic, social distancing has been adopted widely in the United States. Health care is a major exception to social distancing. Although many routine outpatient encounters have been cancelled or converted to telehealth,3CMS Medicare Learning NetworkMedicare fee-for-service (FFS) response to the public health emergency on the coronavirus (COVID-19). March 20, 2020.https://www.cms.gov/files/document/se20011.pdfDate accessed: March 26, 2020Google Scholar hemodialysis continues largely unchanged. There are nearly 500,000 in-center hemodialysis patients in the United States in 20204US Renal Data SystemUSRDS 2019 Annual Data Report: epidemiology of kidney disease in the United States.Am J Kidney Dis. 2020; 75: S1-S64PubMed Google Scholar and likely as many as 200,000 health care workers directly engaged in the delivery of hemodialysis care. These 700,000 individuals are unable to practice social distancing while continuing lifesaving dialysis care. The necessity of in-person encounters for the vulnerable dialysis population and its health care workers is the Achilles’ heel in our response to the pandemic, and key issues with COVID-19 and in-center hemodialysis are discussed next. The fact that this fragile population must congregate to receive treatment is our major vulnerability. Although many other chronic medical conditions can be managed with telehealth and social distancing, in-center hemodialysis is an exception. Although several short-term changes can reduce the risk for widespread dissemination of COVID-19 in hemodialysis facilities, these mitigation strategies have limits in the absence of an ability to quarantine. Potential steps include implementing rigorous screening programs at hemodialysis facilities to identify potential cases; reducing crowding in waiting rooms; disinfecting items not typically addressed, such as hand rails on scales, waiting room seats, door knobs, and elevator buttons; and designating hemodialysis patients who are symptomatic as persons under investigation (PUIs), who are tested for COVID-19 and treated with enhanced precautions. Practices for managing PUIs and COVID-19–positive patients who are currently stable vary across dialysis facilities and dialysis providers. Options for PUIs and clinically stable patients with COVID-19 include: (1) dialyzing in place with rigorous use of personal protective equipment (PPE) and isolation if available, and (2) deferring dialysis and referring a patient to a hospital for testing and/or treatment. Although dialyzing in place theoretically increases the risk for COVID-19 for other patients receiving care in the hemodialysis facility, as well as for facility staff, a high proportion of PUIs are negative for COVID-19; missed dialysis can result in worse outcomes for many hemodialysis patients;5Cohen D.E. Gray K.S. Colson C. Van Wyck D.B. Tentori F. Brunelli S.M. Impact of rescheduling a missed hemodialysis treatment on clinical outcomes.Kidney Med. 2020; 2: 12-19Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar,6Wang H. Maintenance hemodialysis and COVID-19: saving lives with caution, care and courage.Kidney Med. 2020; 2Abstract Full Text Full Text PDF Scopus (33) Google Scholar and if negative, transferring dialysis patients with symptoms to an alternative health care setting could increase their exposure to COVID-19. Critically, although some individuals may be contagious when only minimally symptomatic,7Rothe C. Schunk M. Sothmann P. et al.Transmission of 2019-nCoV infection from an asymptomatic contact in Germany.N Engl J Med. 2020; 382: 970-971Crossref PubMed Scopus (2830) Google Scholar,8Chan J.F. Yuan S. Kok K.H. et al.A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.Lancet. 2020; 395: 514-523Abstract Full Text Full Text PDF PubMed Scopus (6262) Google Scholar asymptomatic or minimally symptomatic individuals were not believed to significantly contribute to transmission in China.9Novel Coronavirus Pneumonia Emergency Response Epidemiology Team[The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China].Zhonghua Liu Xing Bing Xue Za Zhi. 2020; 41: 145-151PubMed Google Scholar In contrast, many patients with upper respiratory tract symptoms will not have COVID-19, suggesting that mandatory transfer of patients to hospitals without dialysis may not be a beneficial policy. Deferring dialysis to a hospital setting may also have substantial negative community effects, increasing hospital expenditure of PPE and stretching hospital dialysis capacities such that hospitals treating PUIs, clinically stable patients with COVID-19 infection, and critically ill patients with COVID-19 infection with kidney failure may not be able to provide the needed care to all these individuals. To reduce risk within hemodialysis facilities providing dialysis to COVID-19–positive patients, it is important that hemodialysis facilities have easy access to rapid COVID-19 testing, sufficient PPE to provide dialysis in place, and sufficient support from local, regional, and national policy makers to implement dialysis-in-place policies. Given these trade-offs, on March 10, 2020 the CDC advised that hemodialysis could be performed on clinically stable patients in the outpatient dialysis setting,10Centers for Disease Control and PreventionInterim additional guidance for infection prevention and control recommendations for patients with suspected or confirmed COVID-19 in outpatient hemodialysis facilities. Updated March 24, 2020.https://www.cdc.gov/coronavirus/2019-ncov/healthcare-facilities/dialysis.htmlDate accessed: March 26, 2020Google Scholar,11Centers for Medicare & Medicaid ServicesCenter for Clinical Standards and Quality/Quality, Safety & Oversight Group. Guidance for infection control and prevention of coronavirus disease 2019 (COVID-19) in dialysis facilities. March 10, 2020.https://www.cms.gov/files/document/qso-20-19-esrd.pdfDate accessed: March 26, 2020Google Scholar and, on March 26, 2020, the End-Stage Renal Disease Networks broadcast that “COVID (+) patients who are stable need outpatient dialysis,” emphasizing the critical importance of limiting hospital use to those who truly require hospitalization. Thus, we advocate that maintenance dialysis patients who are clinically stable receive dialysis in an outpatient setting. Additional steps to reduce transmission in hemodialysis facilities include decreasing the number of patients present at any given time by opening additional shifts, enhanced scheduling to reduce congregation in waiting rooms, increased distancing of patients within a hemodialysis facility, and careful placement of PUIs in isolation rooms or more isolated areas of hemodialysis facilities. Other adopted strategies include designating either entire facilities or specific shifts within a facility for COVID-19–positive patients. All these strategies represent a significant logistic burden but appear essential to optimize use of societal health care resources. Different strategies may be more readily adoptable, depending on local considerations. Unfortunately, there is little that can be done in the short term during the current COVID-19 pandemic to substantially decompress hemodialysis facilities because rapidly transitioning a large number of hemodialysis patients from the outpatient in-center setting to the home setting would be resource intensive and not feasible. This is particularly notable given the current difficulty securing surgeon and operating room availability for peritoneal dialysis catheter placement, reflecting local interpretations that peritoneal dialysis access is not a priority procedure. In the near term, particularly should there be a lull in the current pandemic, rapidly increasing the use of home dialysis will be critical.12Flanagin E.P. Chivate Y. Weiner D.E. Home dialysis in the United States: a roadmap for increasing peritoneal dialysis utilization.Am J Kidney Dis. 2020; 75: 413-416Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar In this regard, the Advancing American Kidney Health Initiative, which promotes substantial increase in the prevalence of home dialysis, was prescient.13US Department of Health and Human ServicesAdvancing American kidney health.https://aspe.hhs.gov/system/files/pdf/262046/AdvancingAmericanKidneyHealth.pdfDate accessed: March 26, 2020Google Scholar The ability to dialyze at home greatly reduces the risk for COVID-19 infection in both patients with kidney failure and the staff needed to care for them, thereby reducing the risk to the entire community. Critically, investment in research and innovation is essential to change our current in-center hemodialysis–centric paradigm of kidney care. In addition to bringing research and innovation into dialysis facilities, a new kidney care paradigm should enhance currently available alternatives to in-center hemodialysis, including home hemodialysis, peritoneal dialysis, and kidney transplantation; develop better strategies and medications to treat chronic kidney diseases and prevent kidney failure; and innovate with new technology to help replace kidney function. Although issues within the hemodialysis facility are challenging, the hemodialysis facility is a controlled environment with a consistent staff and the ability to implement and enforce best practices for infection control. Transportation for hemodialysis patients is a far more haphazard proposition, with many patients relying on state or municipal services to transport to and from their hemodialysis facilities. These services will almost certainly not be equipped with PPE and will not be able to safely transport PUIs or COVID-19–positive hemodialysis patients. Limited solutions exist, particularly for patients who do not have a car or do not have a family member who can reliably transport them to dialysis. This factor, more than any other, may limit the ability of hemodialysis facilities to provide in-center hemodialysis to PUIs and COVID-19–positive patients, resulting in prolonged hospitalizations. One solution is to authorize ambulance transport for these patients from their homes to hemodialysis facilities, but this would likely require substantial support from the state and federal governments given local regulations and recent cuts in reimbursement for nonemergency basic life support transports to and from dialysis facilities.14CMS Medicare Learning NetworkIncreased ambulance payment reduction for nonemergency basic life support (BLS) transports to and from renal dialysis facilities. April 6, 2018.https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/MLNMattersArticles/Downloads/MM10549.pdfDate accessed: March 26, 2020Google Scholar Optimally, collaboration can be enhanced between dialysis facilities and current transportation services to improve driver education, enhance infection prevention, and strengthen communication regarding managing the risk for COVID-19 transmission and potential exposures. With an incubation time of 5 days on average,15Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application [published online ahead of print March 10, 2020]. Ann Intern Med. https://doi.org/10.7326/M20-0504.Google Scholar initial recommendations for quarantine of exposed health care workers were up to 2 weeks.16Centers for Disease Control and PreventionInterim U.S. guidance for risk assessment and public health management of healthcare personnel with potential exposure in a healthcare setting to patients with coronavirus disease (COVID-19). March 7, 2020.https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.htmlDate accessed: March 26, 2020Google Scholar Importantly, asymptomatic health care workers with low-risk exposures, such as encounters that occur when the health care provider is wearing appropriate PPE, are not instructed to self-quarantine but rather recommended to intensively monitor. With the increased availability of testing, exposed health care workers with symptoms may be able to return to work more quickly in the setting of negative test results; however, with the rapid spread of COVID-19 infection in the United States, health care workers will be disproportionately affected. Ultimately, this could limit the availability of in-center hemodialysis or at a minimum affect the ability to add additional hemodialysis shifts for COVID-19–positive patients. COVID-19 has exposed critical weaknesses in our health care system, including our dependence on in-center hemodialysis for more than half a million US residents. This dependence not only increases the likelihood that hemodialysis patients will be infected with COVID-19 but also increases the risk to society, given the health care workers and transportation infrastructure needed to provide in-center hemodialysis. Several steps may help mitigate the current crisis: (1) making every effort to dialyze clinically stable in-center hemodialysis patients in outpatient dialysis facilities to reduce burdens on hospitals, (2) implementing screening, cohorting and isolation processes in hemodialysis facilities, (3) increasing COVID-19 testing in hemodialysis facilities, and (4) observing best PPE practices. However, critically, we as a kidney community need to reduce the vulnerability of patients with kidney disease to future outbreaks and reduce the risks that society faces when providing in-center hemodialysis patients with their life-saving dialysis sessions during a pandemic. The only way to accomplish this is to rapidly change the kidney care paradigm by improving nondialysis kidney care, increasing use of home dialysis and transplantation, and innovating such that in-center hemodialysis is replaced by new technologies that allow patients with kidney failure to live free of dialysis facilities. Daniel E. Weiner, MD, MS, and Suzanne G. Watnick, MD. None. The authors declare that they have no relevant financial interests. Dr Weiner is the American Society of Nephrology representative to Kidney Care Partners and the Editor-in-Chief of Kidney Medicine. Dr Weiner receives support paid to his institution from Dialysis Clinic, Inc, a national not-for-profit dialysis provider. Dr Watnick is the Chief Medical Officer of Northwest Kidney Centers. The opinions in this editorial are the authors’ own and do not necessarily reflect the opinions of any of the mentioned organizations. Received March 25, 2020, in response to an invitation from the journal. Direct editorial input by an Associate Editor. Accepted in revised form March 27, 2020.

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