CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Ying Liang, Smaranda Bacanu, Lekshmy Sreekumar, Anderson Daniel Ramos, Lingyun Dai, Martin Michaelis, Jindřich Činátl, Takahiro Seki, Yihai Cao, Cynthia R. Coffill, David P. Lane, Nayana Prabhu, P. Nordlund
Topics & Concepts
ProteomeThymidylate synthaseProteomicsAntimetaboliteDNA damageRNABiologyMechanism of actionComputational biologyChemistryBiochemistryDNACancerFluorouracilIn vitroGeneticsGeneRNA modifications and cancerBiochemical and Molecular ResearchColorectal Cancer Treatments and Studies