Electron Donor–Acceptor Complex Induced Fused Indoles with Hypervalent Iodine(III) Reagents
Li Liu, Yage Zhang, Wenyan Zhao, Jian Li
Abstract
An operationally simple and efficient method for the cyclization of tertiary amines and hypervalent iodine reagents enabled by an EDA complex has been developed. A series of [1,2-α]indoles derivatives were obtained in good yields, including some key intermediates for the synthesis of biologically active molecules. In addition, this established strategy features a broad substrate scope and good functional group tolerance.
Topics & Concepts
Hypervalent moleculeChemistryReagentIodineCombinatorial chemistryFunctional groupAcceptorElectron acceptorSubstrate (aquarium)MoleculeElectron donorOrganic chemistryCatalysisPhysicsOceanographyPolymerGeologyCondensed matter physicsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions