Enantioselective sulfonylation using sodium hydrogen sulfite, 4-substituted Hantzsch esters and 1-(arylethynyl)naphthalen-2-ols
Xinhua Wang, Qiuping Ding, Chenxi Yang, Jianguo Yang, Jie Wu
Abstract
Synthesis of sulfonyl-containing axially chiral styrenes through a catalytic asymmetric reaction of 4-substituted Hantzsch esters, sodium hydrogen sulfite and 1-(arylethynyl)naphthalen-2-ols is reported.
Topics & Concepts
ChemistryEnantioselective synthesisSulfiteSulfonylCatalysisSodium sulfiteOrganic chemistrySodiumMedicinal chemistryAlkylAxial and Atropisomeric Chirality SynthesisSulfur-Based Synthesis TechniquesAsymmetric Synthesis and Catalysis