Facile synthesis of spherical covalent organic frameworks as stationary phases for short-column liquid chromatography
Qiong Zheng, Yanting He, Wende Ma, Yijing Wu, Zihan Chen, Ran Wang, Wei Tong, Zian Lin
Abstract
Micron-sized spherical covalent organic frameworks (SCOFs) with tunable sizes, narrow size distribution, and significant mono-dispersity were simply synthesized at room temperature. Thanks to their high specific surface areas, high chemical and mechanical stability, the SCOFs were used for the first time as stationary phases for high-efficiency separation of various small molecules and protein digests via short-column liquid chromatography.
Topics & Concepts
Covalent bondChromatographyColumn (typography)Column chromatographyChemistryHigh-performance liquid chromatographyChromatography columnStationary phaseMoleculeMaterials scienceOrganic chemistryComputer scienceFrame (networking)TelecommunicationsCovalent Organic Framework ApplicationsLuminescence and Fluorescent MaterialsMetal-Organic Frameworks: Synthesis and Applications