Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease
Leonardo Brunetti, Rosalba Leuci, Antonio Carrieri, Marco Catto, Sara Occhineri, Giuseppe Vinci, Lucia Gambacorta, Hanna Baltrukevich, Sı́lvia Chaves, Antonio Laghezza, Cosimo Altomare, Paolo Tortorella, M. Amélia Santos, Fulvio Loiodice, Luca Piemontese
Topics & Concepts
ChemistryButyrylcholinesteraseAcetylcholinesteraseDonepezilPharmacophoreDocking (animal)StereochemistryCholinesteraseAchéPharmacologyLead compoundIn silicoBiochemistryEnzymeIn vitroNursingPathologyDementiaDiseaseMedicineGeneCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity