Selective fluorescence turn-on detection of combination cisplatin–etoposide chemotherapy based on N-CDs/GSH-CuNCs nanoprobe
Khalid Alhazzani, Ahmed Z. Alanazi, Aya M. Mostafa, James Barker, Mohamed M. El‐Wekil, Al‐Montaser Bellah H. Ali
Abstract
for ETP along with excellent selectivity against potential interferences in rabbit plasma. Method feasibility was demonstrated with application to real rabbit plasma samples. The method was further applied to estimate the pharmacokinetic parameters of CIS before and after ETP coadministration. The dual nanoprobe sensing strategy enables rapid and selective quantitation of CIS and ETP levels to facilitate therapeutic drug monitoring and optimization of combination chemotherapy regimens.
Topics & Concepts
NanoprobeFluorescenceChemistryEtoposideCisplatinTurn (biochemistry)Cancer researchPhotochemistryChemotherapyBiochemistryMedicineInternal medicineQuantum mechanicsPhysicsNanocluster Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniquesCarbon and Quantum Dots Applications