Relationship between Antibody Levels and SARS-Cov-2 Reinfection.
Mehmet Sami İslamoğlu, Mahir Cengız, Betül Börkü Uysal, Hande İkitimur, Zeynep Özdemir, Ahsen Karamehmetoglu, Ayşe Ezgi Akbulut, Ayşe Nur Bakdur, Azize Ozdemir, Habibe Kayıkcıoglu, Hatice Ozdemir, Rumeysa Uces, Sema Ersoy, Serap Yavuzer
Abstract
OBJECTIVE: In this period when mutant strains are increasing all over the world, studies on how much humoral immunity will protect against the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) are quite limited. The aim of our study is to investigate the positivity and antibody levels of the COVID-19 reverse transcription polymerase chain reaction (RT-PCR) test, the frequency of SARS-CoV-2 re-infection, and the protective antibody level against re-infection. METHODS: Patients who were positive for COVID-19 IgG antibody between 1 July and 31 August were included in our study. The COVID-19 RT-PCR test positivity, age, gender and comorbidities of these patients were recorded before this date. The COVID-19 RT-PCR test positivity of these patients was followed from the National COVID-19 Database between September 1, 2020 and February 28, 2021. RESULTS: <0.001). CONCLUSION: Humoral antibodies against SARS-CoV-2 were protective against COVID-19 reinfection, 0.8% of the patients had reinfection and the resultant reinfection was mostly seen in PCR negative patients who were asymptomatic.