Strategies to transform remote C(sp3)-H bonds of amino acid derivatives
Supreeta Sen, Jayabrata Das, Debabrata Maiti
Abstract
Amino acids and peptides play an important role in nature as well as in the pharmaceutical industry. Therefore, transformation of amino acids and peptides into their unnatural derivatives via step and atom economical ways is highly demanding. Although, a number of methods exist for selective reactions in proximal or -C(sp 3 )-H bond, selective functionalization of distal bonds in amino acids remains a challenge. In recent years, transition metal catalyzed C-H functionalization has come up as a superior tool for C-H bond transformations. In this review, we intend to provide the reader a detailed overview of the current state of art in the utilization of site selective C-H functionalization technology for transformation of distal C-H bonds of amino acids and peptides. Various methods and synthetic tools have been discussed to deliver a broader idea about the field. A systematic compilation has been presented here to provide insights into the recent developments and future challenges in the field.