Electrochemical HI-mediated Intermolecular C–N Bond Formation to Synthesize Imidazoles from Aryl Ketones and Benzylamines
Zan Yang, Jiaqi Zhang, Liping Hu, An Li, Lijun Li, Kun Liu, Tao Yang, Congshan Zhou
Abstract
An efficient and novel electrochemical oxidative tandem cyclization of aryl ketones and benzylamines for the synthesis of 1,2,4-trisubstituted-(1H)-imidazoles has been developed under metal- and oxidant-free conditions. This direct C–N bond formation strategy, with a broad functional group tolerance, affords the desired imidazoles in moderate to excellent yields.
Topics & Concepts
ChemistryIntermolecular forceArylElectrochemistryMedicinal chemistryOrganic chemistryCombinatorial chemistryMoleculeAlkylPhysical chemistryElectrodeCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques