Hantzsch-Like One-Pot Three-Component Synthesis of Heptaazadicyclopenta[a,j]anthracenes: A New Ring System
Ismail A. Abdelhamid, Amr M. Abdelmoniem, Farid M. Sroor, Muhammed A. Ramadan, Said A. S. Ghozlan
Abstract
A concise and efficient approach to novel tetrahydroheptaazadicyclopenta[a,j]anthracene-5,7-diones, by the reaction of aldehydes with two moles of 7-amino-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-5-one is reported. Also, pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-7-carbonitrile derivatives were prepared by a three-component reaction of aldehydes, 7-amino-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-5-one, and 3-aminocrotononitrile.
Topics & Concepts
ChemistryAnthraceneComponent (thermodynamics)PyrimidineRing (chemistry)Combinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryThermodynamicsPhysicsSynthesis and Biological EvaluationCancer therapeutics and mechanismsSynthesis and Reactivity of Heterocycles