Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity
Ying Jing, Yuan Liu, Qiang Li, Youqiong Ye, Lixia Diao, Yun Huang, Yubin Zhou, Michael R. Green, Gordon B. Mills, Leng Han
Topics & Concepts
Chimeric antigen receptorAntigenBiologyCancer researchToxicityReceptorCellImmunologyMolecular biologyImmunotherapyMedicineGeneticsImmune systemInternal medicineCAR-T cell therapy researchAdvancements in Semiconductor Devices and Circuit DesignRenal and related cancers