Palladium-Catalyzed Three-Component Coupling Reaction of <i>o</i>-Bromobenzaldehyde, <i>N</i>-Tosylhydrazone, and Methanol
Lei Zhu, Xiaojian Ren, Yinghua Yu, Pengcheng Ou, Zhixiang Wang, Xueliang Huang
Abstract
A ligand-controlled palladium-catalyzed three-component reaction of o-bromobenzaldehyde, N-tosylhydrazone, and methanol is described. This reaction uses readily available compounds as starting materials while displaying a broad substrate scope and good functional group compatibility.
Topics & Concepts
ChemistryPalladiumMethanolCatalysisCompatibility (geochemistry)Coupling reactionSubstrate (aquarium)Component (thermodynamics)Ligand (biochemistry)Functional groupPolymer chemistryOrganic chemistryChemical engineeringThermodynamicsEngineeringOceanographyPolymerGeologyBiochemistryReceptorPhysicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions