Polarization of macrophages to an anti-cancer phenotype through <i>in situ</i> uncaging of a TLR 7/8 agonist using bioorthogonal nanozymes
Xianzhi Zhang, Yuanchang Liu, Mingdi Jiang, Javier A. Mas‐Rosario, Stefano Fedeli, Roberto Cao‐Milán, Liang Liu, Kyle J. Winters, Cristina‐Maria Hirschbiegel, Ahmed Nabawy, Rui Huang, Michelle E. Farkas, Vincent M. Rotello
Abstract
. The generation of imiquimod resulted in the expression of pro-inflammatory cytokines. The re-educated M1-like macrophages feature enhanced phagocytosis of cancer cells, leading to efficient macrophage-based tumor cell killing.
Topics & Concepts
Bioorthogonal chemistryIn situChemistryPhenotypeAgonistMacrophage polarizationCombinatorial chemistryCancer researchBiochemistryBiologyReceptorClick chemistryOrganic chemistryGeneNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisImmune cells in cancer