Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury
Luoqi Mai, Jinggong Liu, Huimei Wu, Hongshen Wang, Zhidong Lin, Siyuan Rao, Wen-xi Sun, Aowei Tan, Yongpeng Lin, Bolai Chen
Abstract
studies indicate that TSIIA/TMP/APS@Se NPs possess anti-ferroptosis properties and can regulate microglial polarization, potentially enhancing functional recovery following SCI. In summary, this study presents a promising alternative strategy for treating SCI, highlighting its significant potential for future clinical applications.
Topics & Concepts
SeleniumActive ingredientSpinal cord injurySpinal cordPharmacologyNeuroscienceMedicineChemistryBiologyOrganic chemistryNeuroinflammation and Neurodegeneration MechanismsCircular RNAs in diseasesFerroptosis and cancer prognosis