Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing
Lenise Jihe Kim, C Alexandre, Huy Pho, Alban Latrémolière, Vsevolod Y. Polotsky, Luu V. Pham
Abstract
Our diet-induced obesity (DIO) model reproduces sleep features of human obesity, including sleep fragmentation, increased apnea frequency, and larger breathing variability. DIO induces sleep fragmentation independently of apnea severity. Sleep fragmentation in DIO mice is mainly attributed to non-respiratory arousals. Increased breathing variability during sleep did not account for the higher arousal frequency in DIO. Our results provide a rationale to examine sleep in patients with obesity even when they are adequately treated for sleep-disordered breathing.
Topics & Concepts
Non-rapid eye movement sleepSleep and breathingObesitySleep apneaMedicineSleep (system call)ArousalApneaSleep StagesPolysomnographyBreathingAnesthesiaInternal medicinePsychologyEye movementNeuroscienceOphthalmologyOperating systemComputer scienceObstructive Sleep Apnea ResearchSleep and Wakefulness ResearchNeuroscience of respiration and sleep