A terbium(<scp>iii</scp>) luminescent ATCUN-based peptide sensor for selective and reversible detection of copper(<scp>ii</scp>) in biological media
Enrico Falcone, Paulina González, Lucie Lorusso, Olivier Sénèque, Peter Faller, Laurent Raibaut
Abstract
The measurement of exchangeable Cu2+ levels in biological samples is gaining interest in the context of copper-related pathologies. Here, we report a Tb3+ luminescent turn-off sensor for Cu2+ based on the specific and suitable-affinity Xxx-Zzz-His (ATCUN) peptide motif, enabling Cu2+ detection in the presence of a biological fluorescent background.
Topics & Concepts
TerbiumPeptideCopperChemistryLuminescenceFluorescenceLuminescent MeasurementsContext (archaeology)Combinatorial chemistryChemiluminescenceBiophysicsNanotechnologyBiochemistryChromatographyMaterials scienceOptoelectronicsBiologyOrganic chemistryPaleontologyQuantum mechanicsPhysicsMolecular Sensors and Ion DetectionAdvanced biosensing and bioanalysis techniquesElectrochemical Analysis and Applications