Platelets amplify endotheliopathy in COVID-19
Tessa J. Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina C. Rolling, Yuhe Xia, Kamelia Drenkova, Antoine Biebuyck, Alexander T. Fields, Michael Tawil, Elliot Luttrell‐Williams, Eugene Yuriditsky, Grace Smith, Paolo Cotzia, Matthew D. Neal, Lucy Z. Kornblith, Stefania Pittaluga, Amy Rapkiewicz, Hannah M. Burgess, Ian Mohr, Kenneth A. Stapleford, Deepak Voora, Kelly V. Ruggles, Judith S. Hochman, Jeffrey S. Berger
Abstract
represents a promising candidate to reduce proinflammatory platelet-endothelial interactions. Together, these findings demonstrate a previously unappreciated role for platelets and their activation-induced endotheliopathy in COVID-19.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyPlateletMedicineBetacoronavirusImmunologyInternal medicineDiseaseInfectious disease (medical specialty)OutbreakInflammatory Biomarkers in Disease PrognosisHeme Oxygenase-1 and Carbon MonoxideThermal Regulation in Medicine