Defining Critical Genes During Spherule Remodeling and Endospore Development in the Fungal Pathogen, Coccidioides posadasii
Heather Mead, Chandler C. Roe, Emily A. Higgins Keppler, Marley C. Caballero Van Dyke, Klaire L. Laux, Aubrey Funke, Karis J. Miller, Heather D. Bean, Jason W. Sahl, Bridget M. Barker
Abstract
genus. We also found that the wild-type and mutant strains differed significantly in their production versus consumption of metabolites, with the mutant displaying increased nutrient scavenging. Overall, our results provide the first targeted list of key genes that are active during endospore formation and demonstrate that this approach can define targets for functional assays in future studies.
Topics & Concepts
BiologyMicrobiologyFungal pathogenCoccidioidesPathogenGeneOpportunistic pathogenGeneticsVirulenceFungal Infections and StudiesAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases