Pseudomonas aeruginosa Nonphosphorylated AlgR Induces Ribonucleotide Reductase Expression under Oxidative Stress Infectious Conditions
Alba Rubio-Canalejas, Joana Admella, Lucas Pedraz, Eduard Torrents
Abstract
The emergence of multidrug-resistant bacteria is a serious problem worldwide. Pseudomonas aeruginosa is a pathogen that causes severe infections because it can form a biofilm that protects it from immune system mechanisms such as the production of oxidative stress. Ribonucleotide reductases are essential enzymes which synthesize deoxyribonucleotides used in the replication of DNA.
Topics & Concepts
Ribonucleotide reductaseBiologyBiofilmMicrobiologyVirulenceOxidative stressPseudomonas aeruginosaKinaseTwo-component regulatory systemOxidative phosphorylationCell biologyGeneMutantBiochemistryGeneticsBacteriaProtein subunitBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaLegionella and Acanthamoeba research