The brain-specific splice variant of the CDC42 GTPase works together with the kinase ACK to downregulate the EGF receptor in promoting neurogenesis
Makoto Endo, Richard A. Cerione
Abstract
, which is essential for determining its distinct functions. Overall, these findings now highlight a molecular mechanism by which CDC42b and ACK regulate neuronal differentiation and provide new insights into the functional interplay between EGFR degradation and autophagy that occurs during embryonic neurogenesis.
Topics & Concepts
NeurogenesisCell biologyCDC42Neural stem cellBiologyProgenitor cellmTORC1PI3K/AKT/mTOR pathwayEmbryonic stem cellNeuroscienceKinaseStem cellSignal transductionGeneBiochemistryAutophagy in Disease and TherapyMicrotubule and mitosis dynamicsEpigenetics and DNA Methylation