Non-invasive diagnosis of Crohn's disease based on SERS combined with PCA-SVM
Bingyan Li, Yaling Wu, Zijie Wang, Mengmeng Xing, Weimin Xu, Yilian Zhu, Peng Du, Xiaolei Wang, Huinan Yang
Abstract
76.5%). The classification model we established distinguished between aCD and HC with 86.2% sensitivity and 87.5% specificity. It indicates that the metabolic change of patients could be identified by measuring urine with SERS, and aCD and HC could be distinguished more effectively. Our findings are helpful for clinicians to diagnose CD patients and monitor the progress and recurrence of the disease.
Topics & Concepts
Crohn's diseaseSurface-enhanced Raman spectroscopyUrineRaman spectroscopyDiseaseMedicineGastroenterologyInternal medicineChemistryRaman scatteringOpticsPhysicsSpectroscopy Techniques in Biomedical and Chemical ResearchSpectroscopy and Chemometric AnalysesBee Products Chemical Analysis