Efficient Synthesis of Folate-Conjugated Hollow Polymeric Capsules for Accurate Drug Delivery to Cancer Cells
Wenliang Song, Yu Zhang, Deng‐Guang Yu, Chinh Hoang Tran, Menglong Wang, Anuraj Varyambath, Jisu Kim, Il Kim
Abstract
studies against cancer cells demonstrated that FA-HPCs exhibited a more efficient cellular uptake and intracellular doxorubicin release than bare HPCs. This efficient approach to fabricate carbonyl-functionalized hollow organic capsules may open avenues for a new type of morphological-controlled nanoporous polymers for various potential bioengineering applications.
Topics & Concepts
Conjugated systemDrug deliveryNanoporousPolymerCovalent bondChemistryBiomoleculeSurface modificationCombinatorial chemistryNanotechnologyFolic acidDrug carrierMaterials scienceOrganic chemistryMedicinePhysical chemistryInternal medicineCovalent Organic Framework ApplicationsMetal-Organic Frameworks: Synthesis and ApplicationsDendrimers and Hyperbranched Polymers