Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum
Jia Lin, Cuige Zuo, Tianzeng Liang, Yang Huang, Ping Kang, Kan Xiao, Yulan Liu
Abstract
concentration. Notably, LYC potentially alleviated ZEN + DON + AFB1-induced jejunal ferroptosis. These results demonstrate that LYC alleviates ZEN + DON + AFB1-induced jejunal toxicity by inhibiting oxidative stress-mediated ferroptosis and mitochondrial damage in mice.
Topics & Concepts
LycopeneOxidative stressMycotoxinZearalenoneAflatoxinToxicityJejunumToxinChemistryMitochondrionPharmacologyAntioxidantOxidative damageBiologyBiochemistryFood scienceOrganic chemistryFerroptosis and cancer prognosisOccupational and environmental lung diseasesCholangiocarcinoma and Gallbladder Cancer Studies