Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization
Liqiang Su, Jing Feng, Ting Peng, Jinqiao Wan, Jing Fan, Jin Li, Jonathan C. O’Connell, David R. Lancia, G. Joseph Franklin, Guansai Liu
Abstract
2-Aminobenzimidazole cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. Herein, we report a mild protocol for the synthesis of multifunctional 2-aminobenzimidazoles on-DNA with broad substrate scopes. The reaction conditions expand our ability to design and synthesize 2-aminobenzimidazole core-focused DNA-encoded libraries.
Topics & Concepts
ChemistryCombinatorial chemistryDNAIodineSubstrate (aquarium)NanotechnologyDNA synthesisMoleculeOrganic chemistryBiochemistryBiologyMaterials scienceEcologyChemical Synthesis and AnalysisClick Chemistry and ApplicationsSulfur-Based Synthesis Techniques