Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation
Qin Tang, Weitao Fu, Minkui Zhang, Ercheng Wang, Lvhu Shan, Xin Chai, Jinping Pang, Xuwen Wang, Xiaohong Xu, Lei Xu, Dan Li, Rong Sheng, Tingjun Hou
Topics & Concepts
LNCaPAndrogen receptorChemistryVirtual screeningProstate cancerAntagonistPotencyIC50ReceptorDocking (animal)PharmacologyAndrogenComputational biologyCancer researchHormoneCancerDrug discoveryIn vitroBiochemistryInternal medicineBiologyNursingMedicineProstate Cancer Treatment and ResearchEstrogen and related hormone effectsComputational Drug Discovery Methods