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Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Tatjana Schwarz, Pinkus Tober‐Lau, David Hillus, Elisa T. Helbig, Lena J. Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Léon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang‐Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, R Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C. Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M. Corman, Florian Kurth

2021Emerging infectious diseases86 citationsDOIOpen Access PDF

Abstract

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.

Topics & Concepts

VaccinationMedicinePsychological interventionAntibody responseCoronavirus disease 2019 (COVID-19)AntibodyHealth careDiseasePediatricsImmunologyVirologyInternal medicineInfectious disease (medical specialty)NursingEconomic growthEconomicsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesVaccine Coverage and Hesitancy
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany | Litcius