Electrochemical Oxidative Intramolecular N–S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles
Zan Yang, Jiaqi Zhang, Liping Hu, Lijun Li, Kun Liu, Tao Yang, Congshan Zhou
Abstract
A facile and efficient protocol for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles has been developed through the electro-oxidative intramolecular dehydrogenative N-S bond formation of imidoyl thioureas. Various 1,2,4-thiadiazole derivatives were synthesized in good to excellent yields with broad substrate scope and excellent functional group tolerance under catalyst- and oxidant-free electrolytic conditions at room temperature.
Topics & Concepts
ThiadiazolesChemistryIntramolecular forceElectrochemistryOxidative phosphorylationMedicinal chemistryStereochemistryCombinatorial chemistryPhysical chemistryElectrodeBiochemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods