Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase
Antonella Messore, Angela Corona, Valentina Noemi Madia, Francesco Saccoliti, Valeria Tudino, Alessandro De Leo, Davide Ialongo, Luigi Scipione, Daniela De Vita, Giorgio Amendola, Ettore Novellino, Sandro Cosconati, Mathieu Métifiot, Marie‐Line Andréola, Francesca Esposito, Nicole Grandi, Enzo Tramontano, Roberta Costi, Roberto Di Santo
Abstract
cofactor and interact with amino acids of the RNase H domain that are highly conserved among naïve and treatment-experienced patients. In general, the new inhibitors influenced also the polymerase activity of RT but were selective against RNase H vs the IN enzyme.
Topics & Concepts
RNase HReverse transcriptaseIntegraseChemistryRibonucleaseAngiogeninRNase PEnzymeBiochemistryRNase PHActive sitePolymeraseDocking (animal)StereochemistryMolecular biologyRNABiologyDNAGeneGeneticsAngiogenesisMedicineNursingHIV/AIDS drug development and treatmentHIV Research and TreatmentDNA and Nucleic Acid Chemistry