Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates <i>N</i>- and N-<i>O</i>-Acetylated Isomers Controlled by a pH Switch
Kate P. Nolan, Josep Font, Athavan Sresutharsan, Michael P. Gotsbacher, Christopher Brown, Renae M. Ryan, Rachel Codd
Abstract
. The strategy of diversifying protein structure and function using PTMs could be paralleled in secondary metabolites with the use of PBMs.
Topics & Concepts
Hydroxamic acidNonribosomal peptideAcetylationAmine gas treatingSiderophoreStereochemistryChemistryEnzymeMetaboliteBiosynthesisAcetyl-CoABiochemistryOrganic chemistryGenePeptidase Inhibition and AnalysisChemical Synthesis and AnalysisHistone Deacetylase Inhibitors Research