Cinobufagin restrains the growth and triggers DNA damage of human hepatocellular carcinoma cells via proteasome-dependent degradation of thymidylate synthase
Ailin Yang, Qi Wu, Qimei Chen, Jingyi Yang, Haoran Li, Yufan Tao, An-Mei Wang, Yaxue Sun, Jiayu Zhang
Topics & Concepts
Thymidylate synthaseTransfectionCell growthBiologyProteasomeCell cycleCancer researchHep G2CarcinogenesisGene knockdownDNA synthesisDNA damageCell cultureMolecular biologyChemistryCellCancerBiochemistryDNAIn vitroFluorouracilGeneticsDNA Repair MechanismsCancer-related Molecular PathwaysUbiquitin and proteasome pathways