Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Lulu Chen, Jin Peng, You Wang, Huangang Jiang, Wenbo Wang, Jing Dai, Meng Tang, Wei Yan, Hao Kuang, Guozeng Xu, Hui Xu, Fuxiang Zhou
Abstract
via the mitochondria and metabolic reprogramming, demonstrating that mitochondrial regulation and the normalization of cancer cell metabolism are novel therapeutic strategies for cancer.
Topics & Concepts
FenofibrateCancer researchCancer cellLipid metabolismCancerMitochondrionLipotoxicityApoptosisBiologyEndocrinologyMedicineInternal medicinePharmacologyChemistryCell biologyBiochemistryInsulin resistanceInsulinCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated ReceptorsCancer, Hypoxia, and Metabolism