Broad Antimicrobial Resistance in a Case of Relapsing Babesiosis Successfully Treated With Tafenoquine
Ralph Rogers, Peter J. Krause, Ashlyn Norris, Michelle Ting, Ellen H. Nagami, Brian Cilley, Edouard Vannier
Abstract
We describe a case of relapsing babesiosis in an immunocompromised patient. A point mutation in the Babesia microti 23S rRNA gene predicted resistance to azithromycin and clindamycin, whereas an amino acid change in the parasite cytochrome b predicted resistance to atovaquone. Following initiation of tafenoquine, symptoms and parasitemia resolved.
Topics & Concepts
AtovaquoneBabesiosisMedicineAzithromycinParasitemiaClindamycinVirologyMicrobiologyBiologyImmunologyAntibioticsMalariaPlasmodium falciparumVector-borne infectious diseasesInsect and Pesticide ResearchMalaria Research and Control