Surface functionalization of extracellular vesicle nanoparticles with antibodies: a first study on the protein corona “variable”
Angelo Musicò, Rossella Zenatelli, Miriam Romano, Andrea Zendrini, Silvia Alacqua, Selene Tassoni, Lucia Paolini, Chiara Urbinati, Marco Rusnati, Paolo Bergese, Giuseppe Pomarico, Annalisa Radeghieri
Abstract
its natural binding partner (epidermal growth factor receptor, EGFR), but (ii) significant differences emerge at the cellular level, where CTX-EVs prepared by click chemistry display superior binding and uptake toward target cells, very likely due to the higher robustness of the CTX anchorage.
Topics & Concepts
Surface modificationAntibodyExtracellular vesicleNanoparticleExtracellular vesiclesExtracellularSurface (topology)ChemistryCorona (planetary geology)BiophysicsVesicleNanotechnologyMaterials scienceChemical engineeringCell biologyBiochemistryMembraneMicrovesiclesImmunologyBiologyEngineeringMathematicsGeometryGenemicroRNAVenusAstrobiologyPhysical chemistryExtracellular vesicles in diseaseRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery